Vol. 16 No. 3 (2026): 2026 Volume -16 - Issue 3

Published: 2026-07-01

Articles

Navigating the Regulatory Landscape for Combination Products: An Expanded Review of Regulatory Data, Global Perspectives, and Emerging Challenges

Donthamalla Gunasheela, K Srinivasulu, Naddi Thulasi, Ch. Deepika, B. Homeswari, S K Mehara, Gundu Vamshi

641-647

Abstract views: 276
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New Visible Spectrophotometric Method Development for the Quantification of Lasmiditan in Bulk and Its Tablet Formulation

Imam Pasha Syed, Mohammad Maaz, Mohammed Abdul Sayeed, Mohammed Fardeen, Md Zubair biyabani, Anupama Koneru

648-657

Abstract views: 215
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Proniosomal Gel in Ocular Drug Delivery: A Comprehensive Review of Recent Formulation Advances

Amandeep Kaur, Naresh Singh Gill, Diksha Jamwal, Kanika

658-668

Abstract views: 146
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Microwave- Assisted Green Synthesis of Quinoline-Schiff Base Metal Complexes: A Review

Naga Jothy S, Dharani R, Parkavi M

669-680

Abstract views: 112
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Molecular Docking and In-Silico Studies Reveal Aeridin as A Potential Antifungal Agent

S. Surendiran, M. Jeeva, M. Perarasan, P. Vimal, G. Vijo, K. Abhenaya

681-691

Abstract views: 139
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Controlled Release of Cyclosporine via In-Situ Phase Transformation in A Non-Ionic Microemulsion

Hardi Vasvaria, Sonam Gandhi, Bhavin Prajapati

692-712

Abstract views: 139
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Navigating The FDA Regulatory Pathway for Apple's Sleep Apnea Notification Feature: A Regulatory Case Study of Software as a Medical Device (SAMD)

K. Lakshmi Sravani, B Lakshmi Satya, C Soujanya

713-723

Abstract views: 202
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Bacopa+: Evidence Basis and Scientific Rationale for a Standardised Dual-Herb Formulation of Bacopa Monnieri and Curcuma Longa in Cognitive Support, Anxiety Modulation, and Neuroprotection

Rebello L, Chepyala S, Polineni S

724-744

Abstract views: 132
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Standardised Tagetes Erecta Lutein and Zeaxanthin for Macular Health and Visual Performance: A Narrative Review

Rebello L, Chepyala S, Polineni S

745-764

Abstract views: 201
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Self-Emulsified Nanoparticles: Recent Advancements in Formulation, Characterization and Therapeutic Applications (2020–2025)

Kavita, Samriti Sharma

765-771

Abstract views: 152
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Cell Cycle: A multi-nutrient complex targeting one-carbon metabolism, methylation and cellular health: a narrative review of the evidence for eleven micronutrient and phytochemical actives

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

772-790

Abstract views: 268
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Design, Formulation and Evaluation of Fixed-Dose Combination of Telmisartan and Metformin Hydrochloride Filled in Hard Gelatin Capsules

Janvi K. Thummar, Juli B. Trivedi, Nafisa M. Shaikh, Aarti G. Patel, Pooja R. Thakkar, Viral A. Prajapati

791-818

Abstract views: 149
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Coenzyme Q10 and Terminalia Arjuna Bark Extract in Cardiovascular Function and Metabolic Homeostasis: Mechanistic Rationale for the COQ10+ Formulation

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

819-885

Abstract views: 353
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Adhesion-Directed Nutraceutical Intervention for Urinary Tract Health: Clinical Evidence and Mechanistic Rationale for a Cranberry (Vaccinium Macrocarpon) and D-Mannose Combination Formulation

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

886-905

Abstract views: 274
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Nanocurcumin Capsules (Biotex Life Solutions): A Comprehensive Narrative Review of Pharmacokinetic Rationale, Antioxidant Mechanisms, Immunomodulatory Pathways, Safety Considerations, and Translational Evidence

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

906-922

Abstract views: 271
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4DM+: A Scientifically Grounded Botanical Formulation for Metabolic Support and Healthy Glucose Balance — a Narrative Review of Gymnema Sylvestre and Pterocarpus Marsupium

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

923-934

Abstract views: 250
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AC.NET Ayurvedic Almond Oil Cream for Healthy Skin Nourishment (Biotex Life Solutions): A Comprehensive Product-Focused Narrative Review of Sweet Almond Oil, Skin-Barrier Science, Cosmetic Formulation Rationale, Safety, and Translational Evidence

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

935-952

Abstract views: 280
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Spirulina + Chlorella vulgaris as Complementary Nutraceutical Microalgae for Antioxidant, Anti-Inflammatory and Metabolic Support

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

953-985

Abstract views: 244
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MAG Complex: Multi-Salt Magnesium, Potassium Citrate, P5P and Chlorella vulgaris — An Ingredient-Based Narrative Review of the Formulation Rationale and Clinical Evidence for Nerve, Muscle, Cardiovascular, Metabolic and Neuropsychological Indications

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

986-1017

Abstract views: 266
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Hesperidin+ By Biotex Life Solutions: A Comprehensive Narrative Product Review of Antioxidant, Anti-Inflammatory, Antiviral, and Anticancer Evidence

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1018-1037

Abstract views: 261
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Melatonin, Valeriana Wallichii, and Vitamin B6 in A Single Nutraceutical Tablet (Melatonin+): A Critical Review of Mechanistic Rationale, Clinical Utility, Formulation Integrity, and Research Priorities

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1038-1054

Abstract views: 311
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Dandelion+: Scientific Evidence for A Polyherbal Formulation Targeting Hepatoprotection, Antioxidant Defence, and Respiratory Wellness — A Narrative Review of Phyllanthus Amarus, Taraxacum Officinale, and Silybum Marianum

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1055-1064

Abstract views: 224
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Amla Fruit Extract and Vitamin C in Bio C: An Ingredient-Based Narrative Review of Phytochemistry, Antioxidant Mechanisms and Domain-Specific Evidence

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1065-1098

Abstract views: 278
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Broad-Spectrum Free-Form Amino Acid Supplements: Formulation Rationale, Mechanisms, Clinical Evidence and Dose Transferability of an 18-Component Formulation (Amino Complex)

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1099-1127

Abstract views: 273
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Hutchinson-Gilford Progeria Syndrome: A Comprehensive Review of Pathogenesis, Clinical features, Diagnosis and Management

Ganesh Kumar A, Mohamed Shajith S, Nandhini S, Kavinraja A

1128-1136

Abstract views: 118
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B MAX+ as a Multi-Botanical Cognitive and Adaptogenic Nutraceutical: Evidence for Memory, Learning, Stress Modulation and Neuroprotection

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1137-1168

Abstract views: 203
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T MAX+: A Narrative Review of Human Evidence for Mineral and Botanical Ingredients Relevant to Stress Resilience, Physical Performance, Recovery, Hormonal Physiology and General Wellbeing

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1169-1194

Abstract views: 239
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Autologous Exosomes for Human Therapeutics: Biological Basis, Isolation Methodologies, Kit Development, and Translational Requirements

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni, Rani Jangala

1195-1213

Abstract views: 249
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Development of Enrofloxacin-Loaded Biodegradable Polymeric Films for Localized Antimicrobial Therapy

R NARASIMHA RAO, N RAGHUNANDAN, CHIGULLA SRAVANI

1214-1221

Abstract views: 100
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Formulation and In-Vitro Assessment of Alfuzosin Medicated Gummies as a Patient-Friendly Oral Dosage Form

R. Narasimha Rao, N. Raghunandan, Dusari Navya Sree

1234-1245

Abstract views: 103
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Development and Characterization of Venlafaxine Orodispersible Films Incorporating Natural-Synthetic Polymer Blends for Improved Patient Compliance

S. Gopi Krishna, T. Vijaya Kumari, R. Narshima Rao, N. Raghunandan

1246-1254

Abstract views: 102
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Formulation and Evaluation of Buccal Thin Films of Ondansetron Using Biodegradable Natural Polymers (Chitosan-Gelatin) for Rapid Onset of Action

Telagarapu Navya, T.Vijaya kumari, R.Narasimha Rao, N.Raghunandan

1234-1240

Abstract views: 98
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Development of Lornoxicam-Loaded Mucoadhesive Buccal Films Using Biopolymer Blends for Sustained Anti-Inflammatory Effect

Bommu Durga Prasad Reddy, R. Narasimha Rao, N. Ragunandan

1266-1273

Abstract views: 95
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Formulation and Evaluation of Amlodipine-Loaded Natural Polymer-Based Chewable Gummies for Enhanced Patient Compliance and Controlled Release

NAGARAJ, T.VIJAYAKUMARI, R. NARASIMHA RAO, N.RAGUNANDAN

1274-1284

Abstract views: 88
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Formulation and Characterization of Rimegepant-Loaded Polymeric Nanoparticles for Enhanced Solubility and Oral Delivery

T. Vijaya-kumari, R. Narasimha Rao, N. Raghunandan, Rohit

1285-1291

Abstract views: 124
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Formulation and Characterization of Daridorexant Floating Raft-Forming In Situ Gel for Gastroretentive Drug Delivery

RohitArunkanawade, T.Vijaya, R.Narshima, N.Raghunandan

1292-1298

Abstract views: 83
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Formulation and Evaluation of Floating Natural Polymer-Based Microspheres of Doxycycline Hyclate Using Alginate-Xanthan Gum Binary System

R. NARASIMHA RAO, N. RAGHUNANDAN, MD IMTHIYAZ

1299-1306

Abstract views: 80
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Development and Evaluation of a Vericiguat Drug-in-Adhesive Transdermal Patch Using a Hybrid Polyacrylate Silicone Matrix for Controlled Drug Release

Biradar Ajay Kumar, Narasimha Rao, N. Raghunandan

1314-1322

Abstract views: 94
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Formulation and Characterization of Daridorexant Floating Raft-Forming In Situ Gel for Gastroretentive Drug Delivery

Rohit Arun Kanawade, T. Vijaya Kumari, R. Narasimha Rao, N. Raghunandan

1323-1329

Abstract views: 90
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Formulation and Evaluation of pH-Responsive Natural Polymer Raft Gel of Dexlansoprazole for Gastric Ulcer Protection and Sustained Release

R. Narasimha Rao, N. Raghunandhan, Ch. Ramesh

1330-1338

Abstract views: 90
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Formulation and in Vitro Evaluation of The Anticancer Activity of A Hydrogel Containing A Bioactive Fraction Isolated From A Conventional 50% Ethanolic Whole-Plant Extract of Calotropis Gigantea

Sijo Pattam, Rakesh Kumar Jat, G. Nagaraja Perumal

1339-1355

Abstract views: 73
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Beyond Final Testing: Building Quality Through in-Process Quality Control In Pharmaceutical Manufacturing

B.Rakesh, L.V.Vigneshwaran, Dinesh.S, Abu Bakker.A, Madhu.P

1356-1373

Abstract views: 123
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Aloe barbadensis Miller Leaf Extract in Facial Skincare [Bio Wash]: An Ingredient-Based Narrative Review of Hydration, Cleansing- Vehicle Compatibility, Even Tone, Blemish Control, Surface Smoothness and Radiance

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1374-1398

Abstract views: 225
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Thyro Complex by Biotex Life Solutions: An Evidence-Based Narrative Review of Myo-Inositol, Botanical Extracts and Micronutrients Relevant to Thyroid-Related Physiology

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1399-1418

Abstract views: 204
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Exosomes in Hepatocyte Repair and Liver Regeneration: Biological Mechanisms, Autologous Strategies, and Translational Evidence

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni, Rani Jangala

1419-1448

Abstract views: 273
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Multi-Ingredient Weight-Management Formulas [Raspberry+]: A Comparative Dose-Relevance and Evidence-Hierarchy Review of Raspberry, Coffee, Capsaicin, Tea, Garcinia, Cocoa and Zinc.

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1449-1475

Abstract views: 246
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NAD+ Biology and Multi-Component Nutraceutical Support for Cellular Energy, Healthy Ageing, Cognition, Cardiovascular Wellness, Stress Adaptation and Fatigue A Critical Review with Reference to the Biotex NAD+ Formulation

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1476-1499

Abstract views: 201
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Autologous Exosomes and Extracellular Vesicles in Skin Health and Rejuvenation: Biological Mechanisms, Clinical Evidence, Translational Challenges, and the Biotex Autologous Exosome Isolation Kit Structured Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

1500-1518

Abstract views: 291
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Clove+ as a Multi-Botanical Herbaceutical for Gut and Skin Wellness: A Narrative Review of Ingredient-Level Evidence and Convergent Mechanisms

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

519-544

Abstract views: 223
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“Formulation and Evaluation of Topical Herbal Gel Incorporated with Ficus Racemosa Bark Extract for Anti-Inflammatory Activity”

Neha V. Desai, Amruta R. Halijol, Snehal S. Patil, Siddharth P. Daddikar

545-553

Abstract views: 85
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In Silico Screening of Selected Phytochemicals for ADME Properties and Therapeutic Potential in PCOS

Rajendran S.S, Neelaveni Thangavel, Devanarayanana, Nisha. R, Sabeer Ahamed. P, Seenivasan. K, Angalaparameswari. S, Nandhini. S, Vytheeswari.K

554-567

Abstract views: 86
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"Active Charcoal+: Phytochemical Composition, Mechanistic Rationale, and Evidence Appraisal of a Five-Component Ayurvedic Formulation — A Critical Narrative Review"

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

568-589

Abstract views: 218
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Nanoshilajit™: An Evidence-Based Narrative Review of Shilajit in Bioenergetics, Physical Performance, Male Endocrine–Reproductive Health, Recovery, and Physiological Resilience

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

590-611

Abstract views: 236
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Curcuma longa Standardised for Nanocurcumin® and Boswellia serrata in Osteoarthritis-Related Joint Symptoms: A Critical Narrative Review and Evidence Appraisal of Biotex Curcuma + Boswellia Capsules

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

612-634

Abstract views: 214
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Biotex Biosolace Pain Relief Cream: Pharmacological Basis, Topical Analgesic Mechanisms, and Evidence Appraisal of a Multi-Component Ayurvedic Formulation

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

635-657

Abstract views: 197
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A Review on Synthesis and Evaluation of Novel Thiosemicarbazone-1, 2, 3-Triazole Hybrids as Potential Anticancer Agents

Nripendra Singh

658-672

Abstract views: 60
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Topical Hesperidin and Rubia Cordifolia (Manjistha) in Cutaneous Barrier Support, Venous-Stressed Skin and Post-Laser Recovery [HESPERIDIN CREAM]: A Critical Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

673-688

Abstract views: 163
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Topical Phyllanthus Emblica in Biotex C CREAM: Phytochemistry, Cutaneous Disposition and Evidence Appraisal — A Critical Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

689-710

Abstract views: 190
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Bacopa monnieri (Brahmi) in Biotex NIA CREAM: Phytochemistry, Cutaneous Repair Mechanisms, and Evidence Appraisal of a Brahmi Extract Botanical Formulation — A Critical Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

711-734

Abstract views: 150
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A Comprehensive Review of Traditional Uses, Phytochemistry, Pharmacological Activities, Toxicity and Research Priorities of Leucas Aspera (Thumbai)

M. Ponnivalavan, D. Dhachanmoorthi, K. Esakki Muthu, Shalna Shafeek, V. Muhammed Shameem, M.S. Ajay Siddharthan

735-740

Abstract views: 95
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Biotex Nano Carbon Mask: Activated Charcoal and Aloe vera (Aloe barbadensis) for Adsorptive Cleansing, Hydration, and Skin-Soothing Support — A Critical Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

741-757

Abstract views: 199
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Terminalia arjuna Bark Extract and Coenzyme Q10 in Biotex COQ10 Cream: Antioxidant, Bioenergetic and Barrier Evidence in Skin Ageing — A Critical Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

758-775

Abstract views: 196
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Topical Dermatological Potential of Tagetes erecta L. Flower Extract: Phytochemistry, Skin-Relevant Mechanisms, Dermatological Evidence, and Translational Relevance to BIOPANACEA™ Cream — A Narrative Review

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

776-797

Abstract views: 210
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Biotex Saffron Cream: Phytochemistry, Cutaneous Mechanisms, and a Preparation-Aware Evidence Appraisal of Kumkuma (Crocus sativus L.) A Critical Narrative Review of the Scientific Basis for an Antioxidant-Rich Saffron Face Cream

Leroy Rebello1, Sreesudha Chepyala, Sahithi Polineni

798-816

Abstract views: 190
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Role of Emulgel in Enhancing Skin Delivery: A Review

Amandeep Kaur, Amanpreet Kaur, Naresh Singh Gill, Lalit Kumar

816-821

Abstract views: 64
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White Curcumin (Tetrahydrocurcumin) and Manjistha (Rubia cordifolia) in Topical Skin Care: Phytochemistry, Dermatological Mechanisms, and Evidence Supporting Biotex White Curcumin Cream

Leroy Rebello, Sreesudha Chepyala, Sahithi Polineni

822-836

Abstract views: 166
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Formulation and Evaluation of a Novel Herbal Sunscreen Cream Containing Murraya Koenigii, Moringa Oleifera and Erythrina Variegata Extracts

Ganna Anitha, Praveen kumar J, Dhatchayani J, Karmeni S, Saminathan C, Sarojini S

837-842

Abstract views: 74

https://doi.org/10.61096/ijpir.v16.iss3.2026.837-842
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.837-842
Orange Peel Bioactives for Skin Exposome Defense: A Review of Transferosomal Dermaceuticals Against UV Radiation, Blue Light and Air Pollution

Gayathri. R, Haritha.K.S, Jayasurya. S, Kalander Thoufiq. A, Sworna.V, Vijay.V. Vinod

843-851

Abstract views: 44

https://doi.org/10.61096/ijpir.v16.iss3.2026.843-851
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.843-851
NanoCurcumin, Leucas aspera, and Boswellia serrata in Leucas NC Cream: A Critical Review of Convergent Wound-Repair Pharmacology and Translational Potential

Leroy Rebello, Sreesudha Chepyala, Abiram A/L T S Ramalingam, Sahithi Polineni

852-870

Abstract views: 105

https://doi.org/10.61096/ijpir.v16.iss3.2026.852-870
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.852-870
Comprehensive Comparative Quality Assesment and In-Vitro Quality Evalvation of Marketed Boswellia Serrata Herbal Capsule by Using Double Beam UV-Visible Spectroscopy

Dharmasastha S, Aravinth R, Geethaivasan P, Hemalatha V, Sivaranjith M, Harish T, M. Radhakrishnan

871-879

Abstract views: 35

https://doi.org/10.61096/ijpir.v16.iss3.2026.871-879
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.871-879
Formulation and Evaluation of Portulaca grandiflora Ethanolic Extract Herbal Transdermal Patches for Diabetic Wound Management

M. Hasanammal, M. Dinesh Kumar, A. Elsey, P. Muthumariswari, B. Princy, P.M. Thasleema

880-899

Abstract views: 11

https://doi.org/10.61096/ijpir.v16.iss3.2026.880-899
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.880-899
Topical Emulgels of Griseofulvin for Dermatophytosis: Current Trends, Characterization Techniques, and Future Prospects

Ruchi Jain, Piyush Jain, Tekeshwar Kumar

900-913

Abstract views: 24

https://doi.org/10.61096/ijpir.v16.iss3.2026.900-913
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.900-913
Insilico Screening of Nature Resin Phytoconstituents f or Drug – Likeness and ADMET Profiling Against Dual Disease Targets.

Naga Jothy S, Aashika V, Gomathi S, Kalaiselvi K, Keerthana S, Rubini P

914-921

Abstract views: 11

https://doi.org/10.61096/ijpir.v16.iss3.2026.914-921
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.914-921
Origins, History and Development of Ayurveda (As a Brief Review)

T. Mangilal, T. Sowmya, Afreen Banu

922-936

Abstract views: 14

https://doi.org/10.61096/ijpir.v16.iss3.2026.922-936
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DOI: https://doi.org/10.61096/ijpir.v16.iss3.2026.922-936