Formulation and Characterization of Rimegepant-Loaded Polymeric Nanoparticles for Enhanced Solubility and Oral Delivery

ROHIT; T.VIJAYAKUMARI; R. NARASIMHA RAO; N. RAGHUNANDAN

Authors

ROHIT
chowrirohit@gmail.com
Holy Mary Institute of Technology and Science, College of Pharmacy Bogaram, Keesara, Medchal, Telangana, India, 501301.
T.VIJAYAKUMARI Holy Mary Institute of Technology and Science, College of Pharmacy Bogaram, Keesara, Medchal, Telangana, India, 501301.
R. NARASIMHA RAO Holy Mary Institute of Technology and Science, College of Pharmacy Bogaram, Keesara, Medchal, Telangana, India, 501301.
N. RAGHUNANDAN Holy Mary Institute of Technology and Science, College of Pharmacy Bogaram, Keesara, Medchal, Telangana, India, 501301.

Keywords:

Rimegepant, Polymeric nanoparticles, Eudragit RL100, Oral drug delivery, Migraine.

Abstract

The present study was aimed at the formulation and characterization of Rimegepant (RMG)-loaded polymeric nanoparticles (NP) for enhanced solubility and oral delivery. RMG-loaded NP were prepared by the nanoprecipitation method using Eudragit RL100 as polymer and PVA as stabilizer. Preformulation studies confirmed the limited aqueous solubility of RMG and compatibility with selected excipients. The λmax of RMG was found to be 264 nm, and the calibration curve showed good linearity in the range of 2–12 µg/mL. Six formulations were prepared by varying polymer concentration. Among them, F3 showed optimum performance with satisfactory drug content, entrapment efficiency, redispersibility and in vitro drug release. F3 released 85.42% drug within 20 minutes compared with 50.72% release from pure drug. Release kinetics indicated first-order release with anomalous diffusion. Stability studies showed no significant changes during storage. Thus, polymeric NP improved the dissolution behaviour of RMG.

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