Microwave- Assisted Green Synthesis of Quinoline-Schiff Base Metal Complexes: A Review

Abstract

The creation of quinoline–Schiff base metal complexes by microwave-assisted green synthesis has attracted a lot of interest because it is an effective and environmentally friendly method. According to the principles of green chemistry, microwave irradiation permits quick, energy-efficient reactions with little or no solvent. Schiff bases, which are renowned for their exceptional metal-chelating capabilities, and quinoline derivatives, which are known for their varied pharmacological characteristics, combine to produce stable complexes with increased biological potential. Incorporating metal ions like Cu (II), Ni (II), Zn (II), and Co (II) further alters the complexes' physicochemical and biological characteristics. Compared to traditional approaches, this approach has the following benefits: quicker reaction times, higher yields, less solvent use, and less environmental effect. Because of their improved membrane permeability, enhanced lipophilicity, and synergistic actions between the metal and ligand, these complexes show encouraging antibacterial activity. The synthesis methods, structural characteristics, and biological uses of microwave-assisted quinoline–Schiff base metal complexes are highlighted in this review as viable options for the creation of antimicrobial drugs.