ENHANCEMENT OF SOLUBILITY OF QUETIAPINE FUMARATE BY LIQUISOLID COMPACTS TECHNIQUE

Abstract

Pharmaceutical researchers remains uncertain about enhancing the water solubility and dissolution of medications, the objective of this study was to ascertain whether the liquisolid compact formulation of the BCS class II medications Quetiapine Fumarate could enhance its solubility and consequently its dissolution rate to make the Liquisolid compact a number of non volatile solvents were used. Liquisolid preparation made with non volatile solvent labrafac and peccol have shown promising results. Quetiapine Fumarate liquisolid tablets made from peccol or labara dissolve better than other LS formulations, it was found that the best formulations of Quetiapine Fumarate had a hardness of 2.8kg/cm2 a drug release of 99.58%after 10mins, and an angle of repose of 23.24^oC obtained, the results for the designed product made with LS compacts technology showed quick release when compared to the pure medication.