Preparation and evaluation of immediate release tablets of piracetam using super disintegrants

Abstract

The objective of the present study was to develop immediate release tablets of Piracetam in order to achieve rapid release in GIT which might result in enhanced absorption and thereby improved bioavailability. Nine batches of immediate release of Piracetam were prepared by using different ratios superdisintegrants. Drug–excipients interaction was carried out for pure drug and optimized formulations by using FTIR studies. Piracetam tablets were formulated employing different superdisintegrants fusion by direct compression method. All the batches of immediate release tablets were evaluated pre-compression and post-compression parameters. Based evaluation of different parameters it was concluded that formulation of immediate release tablets of Piracetam was successfully done and F6 shows 99.39 % at 45 min.