Effect of polymers in the formulation of sustained release tablets of doxazosin mesylate using various hydrophilic polymers

S. Sowmya; Mohammed Omar; C. Shalini; Ramya Sri. S

Authors

S. Sowmya Department of Pharmaceutics, Arya College of Pharmacy, Sangareddy, Telangana, India. SuraPharma Labs, Dilsukhnagar, Hyderabad, Telangana-500060, India.
Mohammed Omar
suralabs.publications@gmail.com
Department of Pharmaceutics, Arya College of Pharmacy, Sangareddy, Telangana, India. SuraPharma Labs, Dilsukhnagar, Hyderabad, Telangana-500060, India.
C. Shalini Department of Pharmaceutics, Arya College of Pharmacy, Sangareddy, Telangana, India. SuraPharma Labs, Dilsukhnagar, Hyderabad, Telangana-500060, India.
Ramya Sri. S Department of Pharmaceutics, Arya College of Pharmacy, Sangareddy, Telangana, India. SuraPharma Labs, Dilsukhnagar, Hyderabad, Telangana-500060, India.

Keywords:

Doxazosin mesylate, HPM HPMC-K 100 M, Ethyl cellulose, HPC, Eudragit RSPO, Sustained release system

Abstract

The aim of the present study was to develop sustained release formulation of Doxazosin mesylate to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-K 100 M, Ethyl cellulose, HPC and Eudragit RSPO were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (DM5) showed better and desired drug release pattern i.e., 99.21 % in 12 hours. It contains the HPMC-K 100 M 1:1 as sustained release material. It followed peppas release kinetics mechanism.

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