Formulation and in vitro characterization of letermovir extended-release tablets

Abstract

The aim of the present work was to develop an extended-release dosage form of Letermovir. Letermovir is an antiviral drug for the treatment of cytomegalovirus (CMV) infections. Letermovir tablets were prepared using hydrophobic and hydrophilic polymers like Badham Gum, Cashew nut tree gum and synthetic polymers Eudragit L- 100 and HPMC K4M, prepared by direct compression method and evaluated for various pre and post compression parameters. Hydrophobic matrix tablets failed to prolong the drug release, whereas Hydrophilic based matrix tablets showed good drug release.  Whereas from the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e., 99.10 % in  12 hours. It contains the Eudragit L- 100 as extended release material. It followed peppas release kinetics mechanism.