Formulation and invitro evaluation of controlled release matrix tablets of miglitol

Abstract

Oral controlled drug delivery systems have received much attention of the researchers during the past two decades. The rationale for developing a controlled release formulation is to enhance its therapeutic benefits, reducing its side effects and improving the management of diseased condition. Studies have been carried out for developing oral controlled release matrix tablet formulations of Miglitol by using polymeric materials like Tragacanth, Chitosan and Acacia Gum. FTIR Spectral studies shown that drug and excipients used were compatible with each other.  All the formulations were passed various physicochemical evaluation parameters such as Angle of Repose, Bulk Density, Tapped Density, Carr’s Index, Hausners Ratio and Post Compression parameters Weight Variation, Hardness, Thickness, Friability and Drug Content. From the dissolution studies it was evident that the formulation F5 showed better and desired drug release pattern i.e., 99.35 % in 12 hours. It contains the Chitosan as polymer. It followed Zero order kinetics.