Development and evaluation of chlorhexidine mucoadhesive tablets for buccal drug delivery

Abstract

The present investigation is concern with formulation and evaluation of mucoadhesive buccal tablets containing anti anti-infective agent.  Chlorhexidine to circumvent the first pass effect and to improve its bioavailability with reduction in dosing frequency and dose related side effects. The tablets were prepared by direct compression method. Nine formulations were prepared with different polymers like ethyl cellulose, hpmc k 100, eudragit rl with varying concentration. The tablets were tested for weight variation, hardness, drug content uniformity, and in vitro drug dissolution study. Ftir studies showed no evidence on interactions between drug and polymer. The in vitro release of chlorhexidine was performed under sink conditions (phosphate buffer ph 6.8, 37c⁰.5⁰c) using dissolution apparatus usp type ii. The best in vitro drug release profile was achieved with the formulation f3 which contains the drug, hpmc k 100 (15 mg). The formulation f3 containing 5 mg of chlorhexidine exhibited 8 hrs sustained drug release i.e. 99.14%. The in vitro release kinetics studies reveal that formulation fits with higuchi release model.