Efficiency estimation of gastroretentive adhesive aids in drug delivery system

Abstract

Gastro retentive dosage forms have potential for use as controlled-release drug delivery systems. Multiple unit

systems avoid the “all-or-none gastric” emptying nature of single-unit systems. Mucoadhesion is commonly

defined as the adhesion between two materials, at least one of which is a mucosal surface. The potential use for

mucoadhesive systems as drug carriers lies in its prolongation of the residence time at the absorption site,

allowing intensified contact with the epithelial barrier. Mucoadhesive polymers increase contact time for a wide

variety of drugs and routes of administration has shown dramatic improvement in both specific therapies and

more general patient compliance. The general properties of these polymers for purpose of sustained release of

chemicals are marginal in being able to accommodate a wide range of physicochemical drug properties. The aim

of this study is to evaluate the mucoadhesive properties between Polycarbophil, Carbopol and Chitosan.

Comparability of the results is very difficult due to various parameters for the measurements. Until now, there is

no standardized method available for studying mucoadhesion. Chitosan show maximum and prolonged

mucoadhesion of 84.11%.