Formulation and evaluation of mucoadhesive microcapsules of pantoprazole sodium
Keywords:
Pantaprazole sodium, Sodium alginate, Mucoadhesion, methyl cellulose, Hydroxyl propyl methyl celluloseAbstract
The main objective of the study was to design site specific controlled release mucoadhesive micro beads containing
pantoprazole sodium for the treatment of digestive ulcers. Novel Sodium alginate beads containing pantoprazole
sodium were successfully prepared by ion tropic gelation technique with mucoadhesive polymers during
formulation. Sodium alginate (SA), sodium carboxy methyl cellulose (SCMC), Methyl cellulose (MC) and Hydroxy
propyl methyl cellulose (HPMC) were suitable biodegradable and biocompatible synthetic polymers for preparing
intestinal mucoadhesive beads. These includes no risk of dose dumping, flexibility of blending units with different
release patterns, relative merits of bioavailability more consistent blood levels, reproducible and all or none effects.
Nine formulations were prepared and labelled as F1, F2, F3, F4, F5, F6, F7, F8, and F9. Overall, the mucoadhesive
beads provided a prolonged and controlled release that would be beneficial for therapy of digestive ulcers. The %
yield of all batches was found to be in the ranges of 97.14–99.33%. The mean particle size was obtained in the range
of 927.54 – 1012.32µm and 955.36 – 1041.29µm for uncoated and coated beads respectively. Mucoadhesion test
showed a significant effect on mucoadhesive property. The greater the polymer concentration associated with
mucoadhesive alginate matrix, greater will be the adhesion. An increase in drug load has no effect on mucoadhesive
property.
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