Formulation and Evaluation of Cefuroxime Axetil Oral Suspension

Abstract

The oral route is considered the most convenient and easy route of drug delivery. Yet, patient noncompliance, termed “intelligent
noncompliance,” due to feeling better, bad taste, etc., which is reasoned out by the patient but may not necessarily be wise, is one of
the key causes of failure of oral dosage regimen. Paediatric and geriatric populations are most sensitive to the bad taste of medicaments.
Also, currently there is a rising trend to formulate drugs in the form of orally disintegrating dosage forms due to their easy ingestion
and absorption process. Thus, in these cases a good taste is indispensable to patient compliance. Moreover, high palatability
gives a competitive advantage, especially in the case of over-the-counter products. In this review, we will discuss how taste is
perceived, what techniques are available for taste masking, selection of appropriate taste masking technique, and evaluation tests for
the same. Initial six formulations were taken by without adding IPA & talc to the Complexation p a r t . So the dissolution was not
improving. But in the formulations F7-F9 IPA and talc was incorporated into the Complexation part. Here talc improved the
solubility of the Cefuroxime axetil: Betacyclodextrin complex. For initial 2 formulations taste was not good, bitter taste and the
dissolution was not in the limit. For formulations F3-F6 taste was good, slightly bitter taste and the dissolution was not in the
limit. For formulations F7-F9 the taste was good, slight bitter after taste and the dissolution were increasing with increasing the
concentration of Talc. In the case of F9 slight irritation on the throat occurs when increasing the talc concentration. So F7 was
chosen as best formulation