Mcc Utilization In Developing Losartan Potassium And Hydrochlorothiazide Tablets Designs

Abstract

This study aims to develop Losartan Potassium and Hydrochlorothiazide tablets using microcrystalline cellulose (MCC) as a primary excipient. The objective is to create a stable, effective formulation that ensures consistent drug release and therapeutic efficacy. Preformulation studies evaluated the physical, chemical, and mechanical properties of the active pharmaceutical ingredients (APIs) and their interaction with various excipients. The optimal formulation was identified through a series of trials, focusing on parameters such as bulk density, tapped density, angle of repose, and Carr's index. Tablets were prepared using wet granulation followed by compression, and the final product was evaluated for weight variation, hardness, friability, disintegration, and dissolution. Accelerated stability testing was conducted to assess the shelf life under various storage conditions. The results demonstrated that the tablets possessed excellent flow properties, uniform drug content, and acceptable physical characteristics. The dissolution profile indicated that the formulation achieved the desired release rate, meeting the USP specifications for both Losartan Potassium and Hydrochlorothiazide. The study concludes that MCC is an effective excipient for developing robust and reliable tablet formulations of Losartan Potassium and Hydrochlorothiazide, providing a viable option for hypertension management