Formulation and development of nanosuspension of bromhexine hydrochloride

Abstract

The aim of the present investigation was to develop, formulate and evaluation of bromhexine hydrochloride nanosuspension for treatment of bronchial asthma. Bromhexine hydrochloride is a mucolytic agent used to treat respiratory diseases associated with viscid or excessive mucus accumulated in respiratory tract. The present research involved to find out the effect of differ• ent polymer and their ratio on the formulation of Bromhexine hydrochloride oral nanosuspension. The prepared nanosuspension were evaluated for particle size, zeta potential, SEM analysis, Saturation solubility, drug content, viscosity and In-vitro drug release studies. Saturation solubility studies and In-vitro drug release studies shows that the prepared nanosuspension has increased solubility and diffusion rate compared to pure drug. Among all the formulations, F3 has shown the better results like average particle size of 278-450 nm, zeta poten• tial was found to be 27.3 mv and the drug release was 94.55% for bromhexine hydrochloride at the 12th hour.