Review on gastro - retentive drug delivery system and advancements in controlled release

Abstract

The novel approaches of the Gastro - Retentive drug Delivery system improve the drug Bio - availability and patient compliance by increasing the Gastric residence time and controlling the drug release. Various GRDDS approaches can be utilized to retain the dosage forms in the stomach and to release the drug slowly for an extended period of time. GRDDS can be used to prolong the residence time of delivery system in the stomach. This results in targeting of drug release at a specific site for the systemic or local effects. Various drug which are unstable in alkaline PH, soluble in acidic PH, having narrow absorption window, site of action specific to stomach can be developed by using this technique. Gastro - retentive drug delivery system can be used to overcome challenges associated with conventional oral dosage forms and to release the drug at a specific absorption site to improve the Bioavailability of the drug. Gastro retentive dosage forms greatly improves the pharmacotherapy of stomach by releasing the locally and thus results into high concentration of drug at the Gastro mucosa which can be sustained over a longer duration of time. The challenges include fast gastric emptying of the dosage form which result in poor Bio - availability of drug. The purpose of this paper is to briefly describe the approaches of gastro - retentive drug delivery system such as high density, low density (Floating system), mu co adhesive, Expandable, magnetic system and raft forming system.