METHOD DEVELOPMENT AND VALIDATION OF QUETIAPINE FUMERATE BULK AND IN TABLET DOSAGE FORM BY USING UV-SPECTROPHOTOMETRY

Sudarshan Reddy P; Ashok Reddy S; Karthik varma K; Narasimha Rao D; Panjagala Satyanarayana; NagaRaju T M

Authors

Sudarshan Reddy P
editorijipsr@gmail.com
School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.
Ashok Reddy S School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.
Karthik varma K School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.
Narasimha Rao D School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.
Panjagala Satyanarayana School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.
NagaRaju T M School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.

Keywords:

UV-Spectrophotometry, Quetiapine fumarate, Pharmaceutical dosage form.

Abstract

A simple, fast and reliable Spectrophotometric method was developed for determination of Quetiapine fumarate in pharmaceutical formulation. Spectrophotometrically, Quetiapine fumarate was determined by measuring the 2D-values at 254.76nm with water as background solvent. Analytical Calibration curves were linear within a concentration range from 10 to 50μg/ml. The developed method was applied to directly and easily to the analysis of the pharmaceutical tablet preparations. %R.S.D was found to be 0.33 (Quetipin® tablet; 200 mg) respectively. The percentage recoveries werer 98 - 100% for given methods. The method was completely validated and proven to be rugged. The excipients did not interfere in the analysis. The results showed that this method can be used for rapid determination of Quetiapine fumarate in pharmaceutical tablet with linearity, precision, accuracy specificity and LOD, LOQ.

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