SPECTROSCOPIC METHOD FOR DETERMINATION OF DESLORATADINE IN BULK AND ITS TABLET DOSAGE FORMS.

Authors

  • Satish Bondili School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.
  • Sudarshan Reddy P School of Pharmaceutical Sciences, Vels University, Zameen Pallavaram, Chennai, India – 600 117.

Keywords:

UV-Spectrophotometry, Desloratadine, Antihistaminic Drug.

Abstract

A simple and sensitive spectroscopic method was developed for Desloratadine in pure and its tablet dosage forms. The method has been developed by using its free soluble property in Methanol at ambient temperature. At optimum condition of the experiment the absorbance read at 242 nm. The developed method was validated and applied to the determination of  Desloratadine  in  tablets.  The  linearity  range  for  the  concentration  of  Desloratadine  was  found  to  be  2 -10µg/ml  (r2

>0.996, RSD=1.8), precision (RSD=1.83) and accuracy (RSD<1.8). The LOD (0.11) and LOQ (0.33). The product remains stable up to 8 hours when kept at room temperature. The potency of Desloratadine in marketed product was determined by this method with acceptable precision and reproducibility.

Dimensions

Published

2011-06-13

Issue

Vol. 1 No. 2 (2011): 2011 Volume -1 - Issue 2

Section

Articles
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