Invitro chrecterization: pulsatile drug delivery system with plantago ovata seed mucilage and natural gums
Keywords:
Pulsatile Drug Delivery, Lag Time, Plantago Ovata Seed, Modified Agar, Xanthum Gum, Guar gumAbstract
Chrono therapeutic drug delivery basically refers to the release of drug based on biological needs of the
patients; it is purely related to the circadian rhythm of individuals. Aceclofenac is a first line and safest NSAID
used for Rheumatoid arthritis (RA) which is poorly water soluble used by elders/ Rheumatoid arthritis patients,
who may get morning stiffness and joint pains early in the morning. It generally affects the joints and their
synovial membranes, cartilages, capsules and the muscles supplying them. Pulsatile Drug Delivery System is
administered at bed time but drug is going to be released after a lag time in a burst manner.
In present study Aceclofenac with natural super disintegrants like Plantago ovata seed mucilage &modified agar
in inner fast release core tablet and natural polymers like xanthum gum, Guar gum in different ratios as a
compression coating. The prepared tablets were evaluated for various precompression and post compression
parameters all the results were within the limit. Out of all formulationsF6 &F12 are the best formulations based
on pre-and post-compression parameters and Invitro drug release is 95.7±0.10 & 93.7±0.15 respectively at 10
hrs. Which contains 8% of psyllium mucilage and 10% of modified agar with 1:1 ratio of Xanthum gum and
guar gum as a coating material.
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