Design fabrication and characterization of lovastatin nanoparticles by nanoprecipitation-solvent displacement method
Keywords:
Lovastatin, Factorial Design, Transmission electron microscopy, Differential scanning calorimetry.Abstract
Nanoparticles are particles between 1 and 100 nanometers in size. In nanotechnology, a particle is defined as a small
object that behaves as a whole unit with respect to its transport and properties. Particles are further classified
according to diameter. The present study was to formulate nanoparticles containing Lovastatin prepared with Poly (D,
L Lactide-co- Glycolide) by nano-precipitation-solvent displacement method to achieve a better release profile
suitable for per oral administration with enhanced efficacy. The formulations were fabricated according to a 3² full
factorial design, allowing the simultaneous evaluation of two formulation independent variables and their interaction.
The dependent variables that were selected for study were particle size and % drug entrapment. The influence of
various formulation factors (drug: polymer ratio and concentration of surfactants) on particle size, size distribution,
zeta potential, drug loading and encapsulation efficiency were investigated. Encapsulation efficiency and drug
loading capacity were found to be increased as drug concentration increases with respect to polymer. Addition of
surfactants showed a promising result in decreasing particle size of NPs. Dissolution study revealed increased release
of SV from NPs. Transmission electron microscopy (TEM) study revealed spherical morphology of the developed
NPs. Differential scanning calorimetry (DSC) studies confirmed phase transition behavior of NPs. They also showed
very significant change in saturation solubility in comparison with pure drug. The in vitro release data follows matrix
and first order release kinetics mechanism, good correlation coefficients (R2 ≥ 0.9915) could be obtained.
Published
Issue
Section

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.