NEW VISIBLE SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF AMPICILLIN TRIHYDRATE IN BULK DRUG AND THEIR FORMULATIONS

Authors

  • Imam pasha S Global College of Pharmacy, Moinabad, R.R.Dist, A.P, India - 504 501.
  • Fazlu Rehman Global College of Pharmacy, Moinabad, R.R.Dist, A.P, India - 504 501.
  • Taqui Mohammed Global College of Pharmacy, Moinabad, R.R.Dist, A.P, India - 504 501.
  • Sanjyothi Y Global College of Pharmacy, Moinabad, R.R.Dist, A.P, India - 504 501.
  • Shravan kumar A Global College of Pharmacy, Moinabad, R.R.Dist, A.P, India - 504 501.

Keywords:

Ampicillin trihydrate, Ferric chloride, 1, 10 Phenanthroline, 2, 2 Bipyridyl, Spectrophotometry.

Abstract

Two simple, sensitive and economical spectrophotometric methods were developed for the determination of ampicillin trihydrate in pharmaceutical formulations. Method A is based on the formation of pink colored complex by the reaction of drug with ferric chloride and 2, 2 bipyridyl, which absorbs maximally at 500 nm. Method B is based on the formation of orange colored complex by the reaction of drug with ferric chloride and 1,10 phenanthroline, which absorbs maximally at 523nm.Beer’s law is obeyed at a concentration range of 1-10 and 1-12 mcg/ml for method A and method B. Both the methods have been successfully applied for the assay of the drug in pharmaceutical formulations.

Dimensions

Published

2012-02-23

Issue

Vol. 2 No. 1 (2012): 2012 Volume -2 - Issue 1

Section

Articles
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