FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF TRAMADOL HYDROCHLORIDE

Authors

  • Chaudhari Prafulla D Shree Sureshdada Jain Institute of Pharmaceutical Education & Research, Jamner, Jalgaon district, Maharashtra, India – 424 206.
  • Barhate S D Shree Sureshdada Jain Institute of Pharmaceutical Education & Research, Jamner, Jalgaon district, Maharashtra, India – 424 206.
  • Bari M M Shree Sureshdada Jain Institute of Pharmaceutical Education & Research, Jamner, Jalgaon district, Maharashtra, India – 424 206.
  • Patil P P Shree Sureshdada Jain Institute of Pharmaceutical Education & Research, Jamner, Jalgaon district, Maharashtra, India – 424 206.
  • Raundal M J Shree Sureshdada Jain Institute of Pharmaceutical Education & Research, Jamner, Jalgaon district, Maharashtra, India – 424 206.

Keywords:

Tramadol HCL, Mouth dissolving tablets, In vitro evaluation, Sublimating agents.

Abstract

Mouth dissolving tablet is a novel dosage form, have several characteristics to distinguish them from the more traditional dosage form. The purpose of this research was to prepare mouth dissolving tablet of tramadol hydrochloride by sublimation method with a view to enhance patient compliance. Tramadol hydrochloride is a centrally acting analgesic, which is orally and intravenously administered drug. The sublimating agent used in this study was camphor & ammonium bicarbonate, The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time and dissolution study. Amongst all formulations, formulation F3 prepared by 5% crosscaramellose sodium & 15% camphor showed least disintegrating time and faster dissolution.

Dimensions

Published

2013-03-21

Issue

Vol. 3 No. 1 (2013): 2013 Volume -3 - Issue 1

Section

Articles
Copyright & Licensing
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