Formulation and evaluation of keterolac tromethamine colon specific drug delivery system

Abstract

The oral route is the most popular route used for administration of drugs, which is due in part to the ease of administration and to the fact that gastrointestinal physiology offers more flexibility in dosage form design than most other routes. Natural polysaccharides are non-extensively used for the development of solid dosage forms for delivery of drugs to the colon. Various major approaches utilizing polysaccharides for colon specific delivery are fermentable coating of drug core. The preparation of the matrix tablets with guar gum and pectin containing keterolac was done by wet granulation method. The average weight was found to be within the prescribed limit. The hardness of the tablets was found to be in the range of 3.34±0.752 to 7.84 ±0.508 (kg/cm2). Thicknesses of the tablets were found to be in the range of 1.14±0.02 to 3.50±0.01 mm for tablets. The friability of the tablets was found to be less than 0.5 %. The invitro drug release profile of these tablets showed delayed release characteristics. Compatibility studies such as DSC and FTIR studies were carried out to understand the drug-polymer compatibility and revealed that there was no possible interaction between them.