Formulation and evaluation of albendazole tablet by using sublimating agent

Abstract

Sublimation technique is one of the promising approaches for the formulation of drug compounds with poor aqueous solubility. The characterization of the prepared tablet was carried such as FTIR, XRD and AFM studies. XRD graph revealed the absence of peak due to sublimation of camphor. The AFM microgram described the uneven surface due to pores formed by sublimation. SEM indicated the circular shapes contrast on the tablet surface formed due to sublimation of camphor. Porosity was the most critical element in the uptake of water, but porosity beyond certain extent is regulated by an effective surface area of the tablet. The concentration of camphor had a little effect because of the limited surface area present in the tablet. Avicel enhanced the liquid transport into a tablet matrix, accelerating both diffusion and capillary action because avicel exhibited the fast aqueous penetration even at low porosity due to the breaking of hydrogen bonds and widening of pores. This phenomenon enhanced the solubility by increasing the surface area and water penetration leading to an increased dissolution.  Thus it may be concluded that the developed novel method for preparing fast dissolving tablets for albendazole increases the porosity and enhances the bioavailability.