Formulation and evaluation of rebampide extended release tablets

Authors

  • B. Shailaja Assistant Professor, Vision College of Pharmaceutical Sciences and Research, Boduppal, Hyderabad.
  • Munija Pancheddula Assistant Professor,Department of Pharmaceutics, Vision College of Pharmaceutical Sciences and Research, Boduppal, Hyderabad.

Keywords:

Rebampide, HPMC (K4M), HPMC K100M

Abstract

The aim of the present study was to develop Extended-release formulation of Rebampide to maintain constant therapeutic levels of the drug for over 12 hrs. Carbopol 71 G, HPMC K100M, HPMC (K4M)  were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F6) showed better and desired drug release pattern i.e., 98.85% in 12 hours. It contains the HPMC (K4M) as Extended-release material. It followed peppas release kinetics mechanism.

Dimensions

Published

2019-10-26

Issue

Vol. 9 No. 4 (2019): 2019 Volume -9 - Issue 4

Section

Articles
Copyright & Licensing
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.