Formulation and evaluation of controlled release matrix tablets of oligomeric proanthocyanidins (OPC)

Abstract

In the present research, an attempt has been made to formulate controlled release matrix tablets of oligomeric proanthocyanidins (OPCs). Matrix technologies have often proven popular among the oral controlled drug delivery technologies because of their simplicity, easy in manufacturing, high level of reproducibility and easy of scale up and process validation. OPCs is a natural anti oxidant used for the treatment of atherosclerosis was chosen as a model drug with an aim to develop a controlled release matrix tablet. Different formulations were prepared by wet granulation method by using different polymers like HPMC, chitosan, guar gum and xanthan gum with different ratios were used in the development of formulations. The prepared tablets were evaluated for   precompression and postcompression parameters with different ratios. All the formulations showed compliance with pharmacopoeial standards. The effect of polymer loading in in-vitro drug release and the mechanism of release/dissolved was studied by different mathematical models. It was found that the OPCs release rate increased with a decreased amount of polymer. This can be adjusted by maintaining the concentration of the suitable polymers. The selected formulations were subjected to stability studies as per ICH guidelines at different temperature and humidity conditions. Among all the formulations the chitosan and combinations of HPMC and chitosan was considered as the optimized formulation.