Formulation And Evaluation of Econazole Transfersomal Gel

Abstract

The aim of the present research work is to formulate a transfersomal gel of Econazole for deeper penetration into skin via topical route. Optimization of transfersomes and their characterization for different parameters are performed. The optimized preparation is evaluated for in vitro efficacy. The selected research work was divided into three phases. The first phase comprised of selection of drugs and excipients, Preformulation studies, preparation, optimization and in vitro characterization of selected carriers, nano vesicular transfersome. Drugs selected were Econazole and nano vesicular carriers selected. In the second phase of work, preparation and characterization of transfersomal gel formulation containing selected novel carrier was carried out. In third phase, prepared delivery system was evaluated for in vitro studies to ensure the behavior of delivery system. The entrapment efficiency percent of deformable vesicles was detected to be in the range of 75.76±5.27% to 91.17±3.84%. The formula F3 showed the small particle size (160.19 nm), and good release pattern. Accordingly, the formula F3 was used to be incorporated to formulate gel. Use of certain skin permeation enhancers with transferosomal Econazole gel is available and potentiates the permeation of the drug. This technique can serve as a potential tool for delivery of various topical drugs without altering the skin structure