Formulation and in vitro evaluation of ito pride fast dissolving tablets using novel super disintegrants

Authors

  • Mohammed Abdul Nayeem Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • Mohammed Uzaif Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • Munnuri Ajay Kumar Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • Mohammed Zahid Hussain Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • Mudassir Nazar Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • V.Lokeswara Babu Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • A. Srinivasa Rao Department of Pharmaceutics, Bhaskar Pharmacy College, Bhaskar Nagar, Yenkapally (V), Moinabad (M), RR. Dist., Telangana, India.
  • Ramya Sri.S Department of Pharmaceutics, University College of Technology, Osmania University, Hyderabad, Telangana, India

Keywords:

Itopride, Fast Dissolving Tablets, Ocimum Mucilage, Gellan Gum, FeenuGreek Seed Mucilage

Abstract

Recent developments in Fast Dissolving tablets have brought convenience in dosing to pediatric and elderly patients who have
trouble in swallowing tablets. The objective of the present study was to prepare the Fast Dissolving tablets of Itopride for the
treatment of functional dyspepsia and other gastrointestinal conditions. There is a need to develop a formulation for this drug
which overcomes problems such as difficulty in swallowing, inconvenience in administration while travelling, and patient’s
acceptability. Hence, the present investigation was undertaken with a view to develop a Fast Dissolving tablet of Itopride which
offers a new range of products having desired characteristics and intended benefits. Superdisintegrant such as FeenuGreek Seed
Mucilage was optimized. The tablets were prepared by direct compression technique. The tablets were evaluated for hardness,
friability, weight variation, disintegration time, and uniformity of content. Optimized formulation was evaluated by in vitro
dissolution test, drug-excipient compatibility. It was concluded that Fast Dissolving tablets of Itopride were formulated
successfully with desired characteristics which disintegrated rapidly and enhanced the patient convenience and compliance. The
water absorption ratio of formulation F8 is higher and shorter wetting time than other formulations. In vitro drug release was
satisfactory the optimized formulation F8 drug release was found to be 97.37 % at 45 min. On the basis of drug release,
disintegration time and wetting studies it can be concluded that the formulation F8 is the optimum formulation.

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Published

2021-06-25