FORMULATION AND EVALUATION OF RAMIPRIL TRANSFEROSOMAL GEL

Abstract

In the present work an attempt was being made to formulate and evaluate topical gel containing Ramipril. Carbopol 971, Sodium CMC and Carbopol 934 were selected as polymers. The drug and excipient compatibility was studied by using FTIR. Nine formulations of gels were prepared by taking different quantities of polymers. The prepared gel was subjected to various evaluation tests like pH, Spreadability, viscosity, content uniformity and diffusion studies conducted up to 12 hrs. All the results were within the limits; by diffusion studies it was observed that formulation F7 shown maximum drug release of 95.49% which was considered as optimized formulation.