SYNTHESIS AND ANTIBACTERIAL STUDIES ON SOME NOVEL DERIVATIVES OF AZETIDIN-2-ONES

Authors

  • Rathinavel G Prist University, Vallam, Thanjavur, Tamilnadu, India–613403.
  • Senthilkumar K L Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu, India- 635205.
  • Sathish Sekar D Padmavathi College of Pharmacy, Dharmapuri, Tamilnadu, India- 635205.

Keywords:

Azetidin-2-one, Vilsmeier-Haack Reagent, Imines.

Abstract

Isoniazid condensed with different derivatives of acetophenone to form hydrazones, using Vilsmeier-Haack reagent to form free aldehyde. The free aldehyde reacts with different free amide (R-NH2) group to form imines(C=N) which on react with Chloro acetyl chloride and Triethylamine to gives Azetidin-2-one derivatives. The structures of the newly synthesized compounds have been established on the basis of their spectral data and elemental analysis. Selected compound were evaluated for antibacterial activity.

Dimensions

Published

2011-08-02

Issue

Vol. 1 No. 3 (2011): 2011 Volume -1 - Issue 3

Section

Articles
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