HEPATOPROTECTIVE ACTIVITY OF ZIZIPHUS OENOPLIA MILL AGAINST CCL4 INDUCED HEPATIC DAMAGE IN WISTER ALBINO RATS

Abstract

The groups of rats pre-treated with Ziziphus oenoplia extract, demonstrated dose dependent inhibition of elevation of the biochemical parameters. Also, the liver weight was significantly reduced in Ziziphus oenoplia treated groups. . In this study significant increase in the total bilirubin content and in the AST, ALT and ALP activities in the CCl₄ treated group could be taken as an index of liver damage. Treatment with ziziphus oenopliaextract inhibited CCl₄ induced increase in total bilirubin and AST, ALT and ALP activities as compared with CCl₄ treated group.