FORMULATION AND EVALUATION OF DELAYED RELEASE PELLETS OF RABEPRAZOLE SODIUM

Authors

  • Muthukumaran M Padmavathi College of Pharmacy, Peryanhali, Dharmapuri, Tamilnadu, India- 635205.
  • Senthil Kumar K L Padmavathi College of Pharmacy, Peryanhali, Dharmapuri, Tamilnadu, India- 635205.
  • Ratnam B C Padmavathi College of Pharmacy, Peryanhali, Dharmapuri, Tamilnadu, India- 635205.

Keywords:

Rabeprazole sodium, Delayed release pellets, Enteric coating.

Abstract

The aim of the present investigation was to prepare delayed release i.e., enteric coated pellets of Rabeprazole sodium by using hydroxypropyl methyl cellulose based sub coating and methacrylic acid copolymer based enteric coating. The different batches of pellets were prepared by drug suspension layering method. Comparative study of dissolution profile of final batch with market preparations was conducted and it was concluded that final batch shown good similarity with market products. The results of the accelerated stability of final formulation for three months revealed that storage conditions were not found any significant changes in final formulation.

Dimensions

Published

2011-07-26

Issue

Vol. 1 No. 3 (2011): 2011 Volume -1 - Issue 3

Section

Articles
Copyright & Licensing
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.