Enhancement of oral bioavailabity of sumatriptan mucoadhesive buccal tablets using various polymers

Abstract

Buccal region of the oral cavity is an attractive target for administration of the drug of choice. Buccal delivery

involves the administration of the desired drug through the buccal mucosal membrane lining of the oral cavity. By

the way improvisation of oral bioavailability of low bioavailability drugs can be achieved. Hence, in the present

work mucoadhesive buccal tablets of Sumatriptan succinate will be prepared using different natural and synthetic

polymers to improve the oral bioavailability. Buccal sustained release matrix tablets of Sumatriptan succinate

containing different grades of HPMC were subjected to in vitro drug release studies in pH 6.8 Buffer for 8 hours.

The cumulative percent of drug released from the formulations F7and F8 at the end of 8 hrs is 93.45±0.52,

97.04±0.7 respectively. Thus the formulation of aforementioned depicts that the bioavailability of the drug has

been notably increased.