Design and evaluation of microparticles containing didanosine for oral administration

Abstract

For the last so many decades of conventional dosage forms like tablets , capsules, pills, powders, parenteral

preparations, emulsions, creams , ointments , solutions, suspensions and areosals are used in the treatment of acute

and chronic diseases. However the objective of any drug delivery system is to provide drug in therapeutic amount

to the proper site in the body to achieve immediately and then maintain the desired drug concentration. And hence

only the aim of the current investigation is to design and evaluate the microparticles containing Didanosine. The

short term stability study was performed as per ICH guidelines using selected Didanosine -loaded HPMC micro

particles for a period of 3 months. The designed novel drug delivery system has provided a better drug

bioavailability considering, high penetration property of the microparticles encapsulated agents through biological

membrane and the stability. It has been found conducive to prepare the microparticles containing Didanosine.