Studies on hepatoprotective and nephroprotective activities on ethanolic extracts of bauhinia tomentosa

Abstract

In this current investigation the hepatoprotective and nephroprotective activity of ethanol extract of Bauhinia

tomentosa on Paracetamol induced nephrotoxicity in male Wistar rats. In this model of nephrotoxicity, 30 adult

male wistar rats (150-200gms) were evenly divided into 5 groups. Group-1 and Group-2 served as untreated

and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously

treated with standard, 200 and 400 mg/kg extract respectively, after each dose of Paracetamol (200 mg/kg,

i.p. for 3 days) from 4 to 14 days. On 11th day, blood samples for biochemical parameters, while the rats kidneys

for histology were obtained under inhaled diether anaesthesia. Paracetamol treatment caused hepato and

nephrotoxicity as evidenced by marked elevation in blood urea, uric acid and creatinine, bilirubin. Co

administration of extract with Paracetanmol decreased rise in blood urea, uric acid and creatinine, bilirubin.

Apart from these, histopathological changes also showed the protective nature of extract against Paracetamol

induced necrotic and hepatic damage of renal and hepato tissues. It was observed that the ethanol extract

of nephroprotective and hepatoprotective activities by histopathological and biochemical observation against

Paracetamol induced nephrotoxicity and hepatotoxicity in rats. In the near future could constitute a lead to

discovery of a novel drug for treatment of drug induced nephrotoxicity and hepato toxicity.