STUDIES ON ANTIVIRAL ACTIVITY OF 2,3-DIPHENYLQUINOXALINE

Authors

  • Selvam P Devaki Amma Memorial College of Pharmacy, Chelembra, Kerala, India – 673 634.
  • Chandramohan M Bharat Ratna Kamarajar Liver Hospital and Research Centre, Madurai, India - 625 001.
  • Christophe Pannecouque Rega Institute for Medical Research, Katholieke Universiteit-Leuven., Minder broederstraat 10, Leuven B-3000, Belgium.
  • De Clercq E Rega Institute for Medical Research, Katholieke Universiteit-Leuven., Minder broederstraat 10, Leuven B-3000, Belgium.

Keywords:

Microwave Irradiation Technique, 2,3-Diphenylquinoxaline, Anti-HIV Activity.

Abstract

2,3-Diphenylquinoxaline (DPX) have been synthesized by condensation of benzil and O-phenylenediamine by microwave irradiation technique. Their chemical structure was assigned by means of spectral analysis (FT-IR, 1H-NMR, MS). 2,3- diphenylquinoxaline (DPX) was tested for antiviral activity against Human immunodeficiency virus (HIV) -1 and 2 in Metallothionein (MT) - 4 cells and Hepatitis C virus (HCV) in Human Hepatoblastoma cells (Huh) -5-2 Cells. DPX active against replication of HIV-1(IIIB) in MT-4 cells.

 

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Published

2011-06-16

Issue

Vol. 1 No. 2 (2011): 2011 Volume -1 - Issue 2

Section

Articles
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