DESIGN, DEVELOPMENT AND CHARACTERIZATION OF MOUTH DISSOLVING TABLETS OF CEFIXIME

Abstract

Mouth dissolving tablets as a novel dosage form, have several characteristics to distinguish them from the more traditional dosage forms. Taste-masking is of critical importance in the formulation of an acceptable MDT. Traditional tablet formulations generally do not address the issue of taste masking, because it is assumed that the dosage form will not dissolve until passing the oral cavity. Many oral suspensions, syrups and chewable tablets simply contain flavours, sugars and other sweeteners to overcome or complement the bitter taste of the drug. The Current methods of taste masking in fast dissolving/disintegrating  tablets  include  sweeteners  and  flavours.  However,  these  are  not  a  sufficient  means  for  taste- masking many bitter drugs. Most of the MDT technologies incorporate unique forms of taste masking as well.