FORMULATION AND EVALUATION OF AMBROXOL HYDROCHLORIDE TABLETS USING EUDRAGIT RS-100

Abstract

The Goal of this study was to design and evaluate the oral controlled release Ambroxol hydrochloride tablets. Controlled release matrix tablets of Ambroxol hydrochloride were prepared by using polymer, Eudragit RS100 (Drug: polymer 1:0.5, 1:0.75, 1:1 ratio) by wet granulation method and Compressed into tablets. The granules were evaluated for the angle of repose, Bulk density, tapped density, bulkiness, Compressibility index, and Hausner ratio. The granules showed satisfactory Flow properties. The tablets were subjected to weight variation test, hardness test, Friability test and drug content test. All the tablets were passed the tests. The invitro release studies were carried out in the phosphate buffer pH 7.4 for 10 hours using an USP type dissolution apparatus. The rate of release data to kinetic analysis, it was observed that the release of all the formulation followed the mechanism of both diffusion and erosion. And all the formulations are stored at 45°±2°C (RH 75±5%) and the stability studies carried out for 45days. It showed that all the formulations are physically and chemically stable.