FORMULATION AND OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF AN ANTI HYPERTENSIVE DRUG BY DRY GRANULATION METHOD

Abstract

The present study is planned to develop Candesartan cilexetil into immediate release tablets. Generally dry granulation is followed for the drugs that are sensitive to the moisture .Here the dry granulation was developed as a cost effective step towards the manufacturing compared to the wet granulation. The stability of the drug was also assured in the dry granulation process due to the absence of the moisture. So wet granulation method was avoided. All the mentioned batches were done by dry granulation method by roller compaction. Granules were evaluated for tests such as bulk density, tapped density, compressibility index and Hauser’s ratio and sieve analysis before compression. Tablets were tested for weight variation, thickness, hardness, friability and dissolution. In vitro dissolutions were performed and Difference factor (f₁) and similarity factor (f₂) values were calculated. Dissolution profile of Trail V was found to have high similarity with marketed (innovator) formulation. First order dissolution model was constructed.