DISSOLUTION ENHANCEMENT OF PIOGLITAZONE HYDROCHLORIDE USING β- CYCLODEXTRIN

Authors

  • Sowmya C Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, India – 515 721.
  • Suryaprakash Reddy C Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, India – 515 721.
  • Bharath kumar G Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, India – 515 721.
  • Siva Prasad N Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, India – 515 721.

Keywords:

Pioglitazone hydrochloride, β–cyclodextrin, Inclusion complex, Angle of repose, Invitro dissolution.

Abstract

Pioglitazone hydrochloride is an oral anti diabetic drug. It is poorly soluble in water. In the present investigation an attempt was made to increase the solubility and dissolution of Pioglitazone by preparing β- cyclodextrin complexes in different ratios. Prepared inclusion complexes were evaluated for angle of repose, Carr’s index, Hausner’s ratio and in vitro dissolution studies. The in vitro dissolution studies had shown that the complexes containing pioglitazone hydrochloride: β cyclodextrin in 1:10 ratio had shown better enhancement in dissolution rate when compared with other ratios.

Dimensions

Published

2012-07-02

Issue

Vol. 2 No. 3 (2012): 2012 Volume -2 - Issue 3

Section

Articles
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