PREPARATION AND IN VITRO EVALUATION OF BUCLIZINE ORAL THIN FILM STRIPS

Authors

  • Vijaya Kuchana R.G.R. Siddhanthi College of Pharmacy, Secunderabad - 500 003, A.P, India.
  • Deepthi Kammila R.G.R. Siddhanthi College of Pharmacy, Secunderabad - 500 003, A.P, India.
  • Sunitha Sampathi National Institute of Pharmaceutical Education and Research, Hyderabad - 500 037, A.P, India.
  • Pamu Sandhya Shadan Womens College of Pharmacy, Khairatabad, Hyderabad - 500 004, A.P, India.
  • Amareshwar S R.G.R. Siddhanthi College of Pharmacy, Secunderabad - 500 003, A.P, India.

Keywords:

Antihistaminic, Buclizine, Oral thin film strips.

Abstract

Buclizine is an antihistaminic water soluble drug. The objective of the present investigation was to improve bioavailablity of buclizine oral thin film strips by using solvent casting method with excipients. Water soluble synthetic polymer (Poly Vinyl Alcohol), plasticizer (PVP), solubilizer (PEG400), carbapol, sweetener (Mannitol) was used in the preparation of oral thin film strips of buclizine. The oral thin films of buclizine were prepared by solvent casting method using 1:1 and 1:2 ratios of drug and polymers. The influence of the proportion of polymer and several co-excipients on the release rate of the drug from formulations was studied.

Dimensions

Published

2023-09-19

Issue

Vol. 4 No. 2 (2014): 2014 Volume -4 - Issue 2

Section

Articles
Copyright & Licensing
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.