Formulation and Evaluation of Controlled Drug Delivery System of Isometheptene mucate for Enhanced Therapeutic Efficacy

Abstract

In the present study isometheptene mucate is formulated into gastro retentive floating tablets, which is a thiophene derivative; it acts as a serotonin and adrenaline selective neurotransmitter uptake inhibitor. Based on the FTIR compatibility between the drug and polymers and review of literature an attempt was made to prepare floating tablets of the drug, where sodium alginate, Klucel HXF, Methocel K100 were selected as release retarding agents. Total 9 trials were made, of which sodium alginate and Klucel HXF were used till trial F-3, and then only eudragit was used till trial F-09 with varying concentrations. Drug release was satisfactory in trial T-06. F-4 to F-6, proportional increase of hydrophilic polymer Klucel was taken, in same ratio lag phase and floating time were attaining satisfying timings. Physical characterization of all trials for F-4 to F-6 were showing good results and are within the limits according to standard specification. A further attempt in formulation of floating tablets of Isometheptene mucate was carried out by taking MCC from F-4 to F- 6 in increasing proportionate. The drug release obtained was taken for determination of release rate kinetics by interpreting the data in different kinetic models.