FORMULATION AND EVALUATION OF ELETRIPTAN HYDROBROMIDE PELLETS

Abstract

The aim of the present study was to formulate and evaluate Eletriptan hydrobromide pellets. Eletriptan hydrobromide Immediate and controlled release pellets were prepared by Solution/Suspension layering technique by using croscarmellose and povidone in former case and three different polymers HPMC K 100, Ethyl cellulose and Eudragit RS 100 as rate controlling polymer in four different ratios like 1:0.5, 1:1, 1:1.5 and 1:2 to achieve desired release in later case. Evaluation was performed according to the Pharmacopoeia standards including Drug Excipients compatibility, Percentage yield, Particle size distribution, Drug content analysis and in-vitro release study. The best results were found to be using Eletriptan and Eudragit RS 100 in 1:2 ratios. A broad variety of drug release pattern could be achieved by variation of polymers ratios which was optimized to match the target release profile. In comparison of in-vitro release studies for different controlled release formulations, F12 releases 98.54% of drug at the end of 12th hour and was considered as best formulation. Stability study has shown no significant change in the drug content analysis and in-vitro dissolution study of best formulation even after 6 months. The stability data were analyzed using software “Stab”, predicted shelf life period of best formulation was estimated at 14 months.