LIPID AND KIDNEY FUNCTION TEST PROFILES AND THEIR ASSOCIATED RISK FACTORS AMONG HYPERTENSIVE PATIENTS AT FELEGEHIWOT REFERRAL HOSPITAL, BAHIR DAR, NORTHWEST ETHIOPIA

Abstract

Hypertension speeds up the process of hardening of the arteries which makes vulnerable to atherosclerosis formation and damages tiny blood vessels within the kidney. As a result, dyslipidemia becomes one of the most common risk modificator and quantitative risk categorization among hypertensive patients and hypertensive kidney disease becomes a major cause of morbidity and mortality. Although evidences present these, there is scarce data in Africa and as far as to our knowledge there is no data in Ethiopia about lipid and Kidney function test profiles among hypertensive patients. To determine prevalence of dyslipidemia, chronic kidney disease and each kidney function test profile abnormality and to identify their associated risk factors among hypertensive patients at Felegehiwot Referral Hospital from March 26- April 25, 2012. A cross-sectional study was conducted among all hypertensive patients (123) at Felegehiwot Referral Hospital hypertensive clinic from March 26- April 25, 2012. After getting consent from each study subject data was collected by trained data collectors and lab tests were performed by lab personnel to determine prevalence of dyslipidemia, chronic kidney disease and each kidney function test profile abnormality. Then the collected data was cleared and entered with statistical software Epi Info version 2002 and analyzed for proportion and association using SPSS version 16 by the principal investigator. While, there was very high dyslipidemia (78.0%) in at least one of the criteria and chronic kidney disease (96.7%); stage 1-2 46.3% and reduced Estimated glomerular filtration rate (Estimated glomerular filtration rate<60ml/min/1.73m²) 50.4% among the study subjects according to adult treatment panel III and united states of national kidney foundation kidney disease outcome quality initiative by Cockcroft-Gault glomerular filtration rate equation respectively. Lipid alteration due to hypercholesterolemia, low high density lipoprotein cholesterol, total cholesterol/high density lipoprotein cholesterol > 5, high low density lipoprotein cholesterol and hypertriglyceridemia was 39.0%, 26.8%, 18.7%, 45.5%, 35.0% while each kidney function test profile abnormality was 67.5%, 8.1%, 8.9%, 52.9%,14.6% for serum creatinine, serum urea,