Synthesis, characterization and analgesic activity scree

Abstract

Benzimidazole 1-carboxylate derivatives were synthesized and investigated for analgesic activity in this study. After synthesis the

compounds were taken for spectral analysis like FTIR, NMR and Mass spectroscopy. Of the benzimidazole compounds tested,

6b,6c and 6d showed remarkable analgesic activity by tail flick method. The analgesic activity of synthesized compounds were

compare with standard drug Diclofenac. The % analgesic activity at 3hfor the compound 6a,6b,6c,6d and diclofenac were found to

be 359.09, 159.09, 268.18, 204.54 and 368.18 respectively. All the 4 synthesized compound shows good analgesic activity

compare with diclofenac. The compound 6athat possess maximum potency. Acute toxicity of the compounds were 100 mg/kg i.p.

mice. It was concluded that presence of CH2CH3,, CH2C(CH3)2 and CH2C6H5 but methoxy groups is important for analgesic

activity by tail flick method.