Synthesis, characterization and biological evaluation of benzimidazole carboxylate derivatives

Authors

  • Rashmi T Assistant Professor, Bharathi College of Pharmacy, Bharathi Nagar
  • Swaroopa HM Assistant Professor, Bharathi College of Pharmacy, Bharathi Nagar
  • Anupama sunny B.Pharma Final Year Student, Bharathi College of Pharmacy, Bharathi Nagar
  • Aysha Hanna KP B.Pharma Final Year Student, Bharathi College of Pharmacy, Bharathi Nagar
  • Finu Faris K B.Pharma Final Year Student, Bharathi College of Pharmacy, Bharathi Nagar

Keywords:

Analgesic activity, 2-(2-methyl-3-nitrobenzyl)-1H-benzimidazole,

Abstract

The present investigation deals with preparation of total of four compounds of benzimidazole carboxylate derivatives,

characterized by IR, 1 H NMR, 13 C NMR and Mass spectroscopy and assayed biological test for analgesic activity. The analgesic

activity of the synthesized compounds was evaluated by tail-flick model as per standard experimental procedure. The test

compounds were administered by making suspension using Tween-40 and normal saline at a dose of 50mg/kg b.w. through i.p.

route. The standard drug, Diclofenac sodium at a dose of 10mg/kg b.w&Aspirin at a dose of 50mg/kg b.w. was used on a parallel

manner for comparison. The compound 6athat possess maximum potency. The compounds 6c, 6d&6b which showed 2nd,3rd& 4th

most potent analgesic activity respectively.

Dimensions

Published

2021-10-12

Issue

Vol. 11 No. 4 (2021): 2021 Volume -11 - Issue 4

Section

Articles
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