Synthesis, characterization of some new [1,3, 4]-oxadiazole derivatives as antiinflammatory interest

Abstract

This Present investigation deals with the design, synthesis, spectral and biological activities studies of some new [l,3,4]-

oxadiazole derivatives. The acid hydrazides derived from 2-(4-isobutylphenyl)propanoic acid and 4-methylthiophenyl acetic acid

were subjected to cyclization with carbon disulphide under basic conditions to yield [l,3,4]-oxadiazol-2-thiones which on

aminomethylation with formaldehyde and primary aromatic/secondary amines afforded a series of Mannich bases. Purity of the

compounds has been confirmed by TLC. The structures of these newly synthesized compounds were established on the basis of

their IR, 1H NMR, 13C NMR, 2D NMR and Mass spectral data. All the title compounds have been screened for their antimicrobial

and for anti-inflammatory activities.