Development and evaluation of thiolated chitosan based mucoadhesive pellets using extrusion and spheronization technology

Abstract

Mucoadhesive pellets of diclofenac were prepared using Thiolated Chitosan polymers by Extrusion and

Spheronization method. The characterization of pellets such as Particle size, SEM, Friability, Sphericity, and

Angle of repose was carried out. Thiolated chitosan pellets possessed good mucoadhesive action. Thiolated

Chitosan pellets showed higher mucoadhesion with increasing the quantity of polymer. This was due to the

high value of the thiol moieties on chitosan leading to a much higher concentration of thiolate anions, which

are responsible for the reaction with thiol groups within the mucus gel layer that improves mucoadhesion based

on the covalent attachment.