Emerging era of micro needle mediated transdermal drug delivery

Abstract

Many advantages exist for drug delivery through the skin, including the exclusion of hepatic first-pass metabolism, the monitoring of steady plasma levels, safety, and compliance over orally administered routes. However, the biggest challenge for transdermal delivery is that only a limited number of potent drugs with ideal physicochemical properties can passively diffuse and intercellular permeate through skin barriers and achieve therapeutic concentration by this route. The Microneedle technique is the most advanced physical method that easily bypasses, the stratum corneum and allows the drug to each viable dermis. Microneedle technology possesses tremendous potential considering the variations in types and materials it offers with ease of fabrication and is the next generation of therapeutics. This review focuses on the types of microneedles, and techniques involved in the insertion and delivery of microneedles. The study explores the wide applications of microneedle as potential drug targeting therapy.