Formulation and invitro evaluation of famciclovir floating tablets by using non-effervescent technology

Abstract

The purpose of this research was to develop a novel gastroretentive drug delivery system based on Non-Effervescent

technology for controlled delivery of active agent by using Famciclovir. Tablets were formulated by using direct

compression, and evaluated for several pre compression and post compression evaluation studies including floating

buoyancy studies and in vitro dissolution studies. Among the all formulations F1-F6 floating tablets of Famciclovir

by Non-Effervescent floating. From all the above formulations the floating tablets of Famciclovir, maximum drug

release was shown in F6 formulation containing Guargum as a rate retarding polymer, formulated by using Non

Effervescent floating technique. For the optimized formulation, stability studies were performed and it was identified

that there was no change in the effect of drug release after the stability studies. Among all the rate retarding polymers

we have used Guar gum shows better drug release upto 12hours when compared with other polymers. So Guar gum

was used in the formulations for formulating gastro retentive floating tablets. The marketed comparision for the

optimized formulations were compared and the floating tablets were successfully retarded the drug release in 0.1 N

HCL for 12 hours by using Non-Effervescent floating Technique by using Guar gum.