Design, prepare and evaluation of terbutaline tablets for chrono modulated pulsatile drug delivery system
Keywords:
Terbutaline sulphate, Polymers, FTIR studies, Direct compression technique, Core tablets, Drug release studies.Abstract
Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in
the right amount, thus providing spatial and temporal delivery and increasing patient compliance. These systems are
designed according to the circadian rhythm of the body. Pulsatile drug delivery system for Terbutaline was
formulated initially as core tablets followed by formulation of pulsatile tablets using press-coated technology. Core
tablets were formulated. The core tablets were then compressed into pulsatile tablets using various concentrations of
polymers. Core tablets were evaluated and based on the dissolution studies trial F1 was optimized as it shows lower
disintegration time and faster drug release. Then the pulsatile tablets were evaluated for various tests and drug release
studies were conducted for pH 7.4 buffer. Pulsatile tablets were formulated utilizing press coated technology and the
combination of polymers provided required lag time with satisfactory dissolution profile.
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